This article discusses the regional multi-jurisdictional GIS concept for collaborative organization and service delivery of geospatial data, technology, resources, and services. At the local and regional level, many local government agencies overlap – they share geography. Cities and towns exist within counties, and multiple cities and counties may exist within a regional planning agency. Cities, counties, tribal governments, utilities, and transit agencies may serve the same geographic region. Citizens expect local government agencies to be prudent stewards of financial resources. A collaborative regional, multi-jurisdictional approach to GIS organization and operation provides many opportunities for more cost- effective geospatial services. This article introduces the concept of regional multi-jurisdictional GIS, reviews early history, and outlines the benefits, structures, and challenges involved. Three case studies put the concepts discussed into context.